Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032475 | 0.83 | DDAH1 (0.42) | KDM4EMAPTCHEK1CACNA1BNPC1 | |
| SCHEMBL8805598 | 0.80 | KDM4E (0.40) | KDM4EMAPTCHEK1NPC1ALDH1A1 | |
| SCHEMBL7036353 | 0.76 | HSD17B10 (0.39) | KDM4EMAPTCACNA1BNPC1ALDH1A1 | |
| SCHEMBL7575266 | 0.76 | CACNA1H (0.44) | KDM4EMAPTCHEK1CACNA1BNPC1 | |
| SCHEMBL7032565 | 0.74 | PARP1 (0.42) | KDM4EMAPTCACNA1BNPC1ALDH1A1 | |
| SCHEMBL6756153 | 0.73 | KDM4E (0.44) | KDM4EMAPTGSK3BCACNA1BNPC1 | |
| SCHEMBL8806547 | 0.70 | ADRA2A (0.54) | KDM4EMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7035577 | 0.70 | L3MBTL1 (0.41) | KDM4EMAPTCACNA1BNPC1ALDH1A1 | |
| SCHEMBL4105591 | 0.70 | MGAM (0.46) | KDM4EMAPTALDH1A1GAA | |
| SCHEMBL1075769 | 0.69 | TSHR (0.41) | KDM4EMAPTGSK3BADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775134-A4 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMA CORP (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0775134-A1 | Imidazolin-2-ylaminobenzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004270-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-02-15 | — | — | WO | disclosed |