SCHEMBL8808273

SCHEMBL8808273

CC(=O)O[C@@H]1OCC[C@@H]1NC[C@@H](CC(C)C)NS(=O)(=O)c1cccnc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
ADAM17 P78536 1/20 0.38
ITGAV P06756 2/20 0.38
CAPN1 P07384 2/20 0.37
CAPNS1 P04632 1/20 0.36
HTR1A P08908 1/20 0.35
HTR7 P34969 1/20 0.35
ITGB3 P05106 6/20 0.35
ITGA2B P08514 6/20 0.35
HSD17B10 Q99714 1/20 0.35
ALDH1A1 P00352 1/20 0.34
HCRTR2 O43614 1/20 0.34
ADAMTS4 O75173 1/20 0.34
TBXA2R P21731 1/20 0.34
TBXAS1 P24557 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404245 0.90 CAPN1 (0.42) CAPN1CAPNS1ALDH1A1CA1CA2
SCHEMBL8808500 0.85 CAPN1 (0.41) SLC1A3SLC1A2SLC1A1ADAM17ITGAV
SCHEMBL8808270 0.85 CAPN1 (0.48) SLC1A3SLC1A2SLC1A1ADAM17ITGAV
SCHEMBL8808279 0.85 CAPN1 (0.48) SLC1A3SLC1A2SLC1A1ADAM17ITGAV
SCHEMBL8810086 0.84 CA2 (0.47) CAPN1CAPNS1HSD17B10ALDH1A1CA1
SCHEMBL8406510 0.84 MMP2 (0.38) SLC1A3SLC1A2SLC1A1CAPN1CAPNS1
SCHEMBL8403868 0.83 MMP13 (0.45) HSD17B10ALDH1A1
SCHEMBL8404228 0.82 CAPN1 (0.43) SLC1A3SLC1A2SLC1A1ADAM17CAPN1
SCHEMBL8811338 0.82 CA1 (0.39) CAPN1CAPNS1ALDH1A1CA1CA2
SCHEMBL8813432 0.81 CAPN1 (0.38) CAPN1CAPNS1ALDH1A1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0810221-A1 OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES MITSUBISHI CHEMICAL CORPORATION (JP) 1997-12-03 EP disclosed