Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | HINT1 | P49773 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811718 | 0.92 | LMNA (0.64) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL9620185 | 0.92 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL12219209 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL12194727 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL12939443 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL6221774 | 0.84 | HINT1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL6222354 | 0.84 | ADORA2A (0.52) | ADORA2AADORA2B | |
| SCHEMBL9620169 | 0.84 | ALDH1A1 (0.44) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL18672138 | 0.82 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL6223064 | 0.81 | PRKAB2 (0.46) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547910-B1 | A process for preparing 2-chloro-2'-deoxyadenosine | ORTHO PHARMA CORP (US) | 1997-03-05 | — | — | EP | disclosed |
| EP-0547910-A1 | A process for preparing 2-chloro-2'-deoxyadenosine | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-5208327-A | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0269574-B1 | NOVEL ADENOSINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE INGREDIENT | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4843066-A | HYPOTENSIVE AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0269574-A2 | Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1988-06-01 | — | — | EP | disclosed |