Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | HINT1 | P49773 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620185 | 0.90 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL6223064 | 0.88 | PRKAB2 (0.46) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL8811718 | 0.84 | LMNA (0.64) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL8809236 | 0.84 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL6221774 | 0.82 | HINT1 (0.51) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL6222354 | 0.81 | ADORA2A (0.52) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL9620171 | 0.80 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL6221610 | 0.78 | ADORA2A (0.47) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL6221793 | 0.74 | LMNA (0.35) | ALDH1A1MAPTLMNATP53TDP1 | |
| SCHEMBL6223639 | 0.73 | HPGD (0.48) | ALDH1A1LMNAADORA2AHINT1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269574-B1 | NOVEL ADENOSINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE INGREDIENT | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4843066-A | HYPOTENSIVE AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |