Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809434 | 0.78 | AR (0.50) | GRM2L3MBTL1GAACTSA | |
| SCHEMBL588692 | 0.73 | ESR2 (0.44) | GABRG2GABRB3GABRA3GABRA5ESR2 | |
| SCHEMBL2575065 | 0.73 | GABRA1 (0.39) | L3MBTL1GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL21483572 | 0.72 | NPC1 (0.50) | GRM2L3MBTL1GAAESR2 | |
| SCHEMBL8484254 | 0.71 | KCNH2 (0.40) | GRM2SLC6A2SLC6A4KCNH2L3MBTL1 | |
| SCHEMBL3644296 | 0.71 | ESR2 (0.40) | GABRG2GABRB3GABRA3CA1CA2 | |
| SCHEMBL9313614 | 0.71 | ALDH1A1 (0.40) | CNR2CA1CA2ESR2 | |
| SCHEMBL2649479 | 0.69 | SLC6A2 (0.49) | GRM2SLC6A2SLC6A4KCNH2L3MBTL1 | |
| SCHEMBL899 | 0.69 | CYP19A1 (0.46) | SLC6A2SLC6A4CA1CA2 | |
| SCHEMBL29513232 | 0.69 | CYP19A1 (0.46) | SLC6A2SLC6A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |