Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | DBH | P09172 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810664 | 0.93 | MPO (0.46) | MPOHTR6DBHSLC2A1CYP19A1 | |
| SCHEMBL8810754 | 0.91 | PARP1 (0.41) | MPOHTR6CYP19A1ALDH1A1LMNA | |
| SCHEMBL8810937 | 0.88 | TNF (0.40) | MPOHTR6TNFPARP1P2RX7 | |
| SCHEMBL8685833 | 0.87 | HTR6 (0.43) | MPOHTR6CYP19A1ALDH1A1LMNA | |
| SCHEMBL8810643 | 0.87 | TACR1 (0.39) | LMNASMN1; SMN2PARP1 | |
| SCHEMBL8810072 | 0.86 | PARP1 (0.41) | CYP19A1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8810446 | 0.86 | PPARG (0.38) | MPOHTR6ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8808816 | 0.86 | HTR6 (0.34) | MPOHTR6CYP19A1ALDH1A1LMNA | |
| SCHEMBL8812580 | 0.85 | TNF (0.37) | MPOHTR6CYP19A1TNFPARP1 | |
| SCHEMBL8809697 | 0.85 | HTR6 (0.42) | HTR6CYP19A1ALDH1A1SMN1; SMN2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | claimed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |