Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514459 | 0.84 | TRPM8 (0.46) | TRPM8ALDH1A1HTTCES2CES1 | |
| SCHEMBL10514467 | 0.84 | TRPM8 (0.46) | TRPM8ALDH1A1HTTCES2CES1 | |
| SCHEMBL3469925 | 0.84 | TRPM8 (0.51) | TRPM8ALDH1A1USP2CES2CES1 | |
| SCHEMBL21026944 | 0.84 | ALDH1A1 (0.54) | TRPM8ALDH1A1HTTUSP2CES2 | |
| SCHEMBL10537588 | 0.81 | TRPM8 (0.49) | TRPM8ALDH1A1HTTUSP2CES2 | |
| SCHEMBL11925042 | 0.81 | LMNA (0.51) | ALDH1A1MAPTNPC1SMN1; SMN2TAS1R3 | |
| SCHEMBL25316112 | 0.80 | ALDH1A1 (0.66) | TRPM8ALDH1A1HTTUSP2MAPT | |
| SCHEMBL8812902 | 0.80 | MTNR1A (0.51) | CES2CES1NPC1RAB9AMTNR1A | |
| SCHEMBL4868746 | 0.80 | TRPM8 (0.48) | TRPM8ALDH1A1USP2MAPTNPC1 | |
| SCHEMBL4869949 | 0.80 | GSK3B (0.49) | TRPM8ALDH1A1USP2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078164-B1 | PTEN binding compounds, formulations, and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2021-08-03 | — | — | US | disclosed |
| US-10669241-B2 | PTEN binding compounds, formulations, and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190161450-A1 | PTEN BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF | UNIVERSITY OF SOUTH FLORIDA (US) | 2019-05-30 | — | — | US | disclosed |
| WO-2005118573-A1 | NOVEL DIAZEPINE COMPOUNDS AS LIGANDS OF THE MELANOCORTIN 1 AND/OR 4 RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
| EP-0755394-A1 | A METHOD OF INDUCING CHOLECYSTOKININ AGONIST ACTIVITY USING 1,4-BENZODIAZEPINE COMPOUNDS | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028399-A1 | A METHOD OF INDUCING CHOLECYSTOKININ AGONIST ACTIVITY USING 1,4-BENZODIAZEPINE COMPOUNDS | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10669241-B2 | PTEN binding compounds, formulations, and uses thereof | PTEN, EYA2, PIK3CA | TRPM8 3764/4885ALDH1A1 4148/4885HTT 1284/4885 |
| US-11078164-B1 | PTEN binding compounds, formulations, and uses thereof | PTEN, EYA2, PIK3CA | TRPM8 3764/4885ALDH1A1 4148/4885HTT 1284/4885 |
| US-20190161450-A1 | PTEN BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF | PTEN, EYA2, PIK3CA | TRPM8 3764/4885ALDH1A1 4148/4885HTT 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.