Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436654 | 0.82 | HTR6 (0.52) | HTR6TSHRLMNAALDH1A1GAA | |
| SCHEMBL28422858 | 0.75 | HTR6 (0.73) | HTR6TSHRLMNAMPOCYP3A4 | |
| Dapsone SCHEMBL2031998 | 0.74 | HTR6 (0.89) | HTR6TSHRLMNAMPOCYP3A4 | |
| SCHEMBL324893 | 0.74 | HTR6 (1.00) | HTR6TSHRLMNAMPOCYP3A4 | |
| Dapsone SCHEMBL1219599 | 0.74 | HTR6 (1.00) | HTR6TSHRLMNAMPOCYP3A4 | |
| SCHEMBL10596934 | 0.74 | HTR6 (1.00) | HTR6TSHRLMNAMPOCYP3A4 | |
| Dapsone SCHEMBL21428 | 0.74 | HTR6 (1.00) | HTR6TSHRLMNAMPOCYP3A4 | |
| Dapsone SCHEMBL5055312 | 0.74 | HTR6 (1.00) | HTR6TSHRLMNAMPOCYP3A4 | |
| SCHEMBL6241506 | 0.74 | ALDH1A1 (0.44) | TSHRLMNACYP2C9ALDH1A1CYP2C19 | |
| SCHEMBL900296 | 0.73 | HTR6 (0.76) | HTR6TSHRLMNAMPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658952-A | REDUCTION IN LEVEL OF INFECTION; ANTIPROTOZOA AGENTS | JACOBUS PHARMACEUTICAL CO., INC. (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1997007795-A2 | 1-[4-(4'-SULFANILYL)PHENYL]UREA AND DERIVATIVES FOR THE TREATMENT OF LEISHMANIASIS | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 1997-03-06 | — | — | WO | disclosed |