Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810643 | 0.91 | TACR1 (0.39) | GCGRSMN1; SMN2MAPTPARP1KDM4E | |
| SCHEMBL8809597 | 0.90 | PARP1 (0.47) | ALDH1A1SMN1; SMN2MAPTPARP1KDM4E | |
| SCHEMBL8810754 | 0.89 | PARP1 (0.41) | HTR6ALDH1A1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL8812580 | 0.88 | TNF (0.37) | HTR6MAPTPARP1KDM4EMPO | |
| SCHEMBL8685833 | 0.87 | HTR6 (0.43) | HTR6ALDH1A1MPO | |
| SCHEMBL8811167 | 0.87 | HTR6 (0.53) | HTR6ALDH1A1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL8814121 | 0.87 | PARP1 (0.41) | HTR6CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8811282 | 0.87 | CHRNB2 (0.38) | HTR6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL8811933 | 0.87 | HTR6 (0.41) | HTR6MAPTPARP1MPO | |
| SCHEMBL8808975 | 0.87 | DAO (0.34) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | claimed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |