Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | ENPP2 | Q13822 | 9/20 | 0.64 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.59 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 0.59 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.59 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTPRA | P18433 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846279 | 1.00 | HIF1A (1.00) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL4068193 | 1.00 | HIF1A (1.00) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL10622991 | 0.99 | HIF1A (0.98) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL8947349 | 0.93 | ALDH1A1 (0.87) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL30655205 | 0.87 | HIF1A (0.78) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL4579446 | 0.87 | HIF1A (0.78) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL15424240 | 0.86 | HIF1A (0.76) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL17804082 | 0.86 | CYP1A2 (0.76) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL6846278 | 0.85 | ALDH1A1 (0.74) | HIF1AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL29350187 | 0.85 | ALDH1A1 (0.74) | HIF1AALDH1A1MEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | AMBION, INC (US) | 2007-02-08 | — | — | US | disclosed |
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | AMBION, INC (US) | 2007-02-08 | — | — | US | disclosed |
| WO-1997041844-A1 | COMBINATIONS OF ANGIOSTATIC COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1997-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | RNASE1, RNASEH1, RNASEL | HIF1A 1080/4885ALDH1A1 2603/4885MEN1 2073/4885 |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | HIF1A 3620/4885ALDH1A1 3724/4885MEN1 4323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.