Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GAPDH | P04406 | 2/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | HRAS | P01112 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | POLRMT | O00411 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16480685 | 1.00 | MEN1 (0.46) | MEN1USP2POLBKMT2ACA1 | |
| SCHEMBL881488 | 0.87 | MEN1 (0.47) | MEN1USP2POLBKMT2ACA1 | |
| SCHEMBL881460 | 0.80 | ALDH1A1 (0.38) | MEN1USP2POLBKMT2ACA1 | |
| SCHEMBL16480684 | 0.80 | ALDH1A1 (0.38) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL20058768 | 0.78 | MAPT (0.40) | MEN1USP2POLBKMT2ACA1 | |
| SCHEMBL17129844 | 0.78 | ALDH1A1 (0.36) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL24606380 | 0.76 | NPC1 (0.38) | MEN1KMT2ARIPK1DOT1L | |
| SCHEMBL26240623 | 0.76 | POLRMT (0.36) | MEN1USP2POLBKMT2ARIPK1 | |
| SCHEMBL882017 | 0.76 | TMPRSS2 (0.39) | MEN1USP2POLBKMT2ACA1 | |
| SCHEMBL20059148 | 0.76 | NPC1 (0.38) | POLBALDH1A1RIPK1DOT1LPOLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039791-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |