Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825480 | 0.95 | LTB4R (0.46) | LTB4RTP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL8825418 | 0.83 | PPARG (0.41) | LTB4RALDH1A1HPGD | |
| SCHEMBL8825377 | 0.82 | CYSLTR2 (0.49) | LTB4R | |
| SCHEMBL8825213 | 0.81 | LTB4R (0.58) | LTB4R | |
| SCHEMBL8825437 | 0.77 | LTB4R (0.60) | LTB4RTP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL8825445 | 0.77 | LTB4R (0.60) | LTB4RTP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL9284151 | 0.77 | FFAR1 (0.47) | RARB | |
| SCHEMBL9647259 | 0.75 | TP53 (0.85) | TP53TSHRPLA2G4BPTPN11RARB | |
| SCHEMBL10334290 | 0.74 | ALDH1A1 (0.57) | TP53TSHRPLA2G4BALDH1A1HPGD | |
| SCHEMBL6539348 | 0.73 | TP53 (0.82) | TP53TSHRPLA2G4BPTPN11RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | claimed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | claimed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | claimed |
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |