Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 9/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796541 | 0.85 | EGFR (0.47) | PDGFRBNSD2ACHEMAPK1MAPT | |
| SCHEMBL9224976 | 0.83 | PDGFRB (0.64) | MEN1KMT2APDGFRBACHEMAPT | |
| SCHEMBL8825797 | 0.83 | PDGFRB (0.44) | PDGFRBMAPT | |
| SCHEMBL8825745 | 0.82 | PDGFRB (0.46) | CYP2D6MEN1KMT2APDGFRBNSD2 | |
| SCHEMBL8796240 | 0.81 | EGFR (0.45) | CYP1A2MEN1KMT2APDGFRBMAPK1 | |
| SCHEMBL8796234 | 0.81 | PIK3CA (0.45) | CYP1A2PDGFRBMAPK1MAPT | |
| SCHEMBL8825839 | 0.81 | EGFR (0.62) | MAPK1RAB9A | |
| SCHEMBL8796335 | 0.80 | MAPK1 (0.45) | PDGFRBMAPK1 | |
| SCHEMBL8796603 | 0.79 | LMNA (0.44) | KMT2APDGFRBMAPTNPSR1 | |
| SCHEMBL8825610 | 0.79 | PDGFRB (0.61) | MEN1KMT2APDGFRBACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |