Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 14/20 | 0.43 |
| ▸ | NOS1 | P29475 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828285 | 0.95 | NOS2 (0.46) | NOS2NOS1 | |
| SCHEMBL9159994 | 0.85 | MAOB (0.40) | LMNAMAPTALOX15MAOBTP53 | |
| SCHEMBL8828152 | 0.85 | TMEM97 (0.43) | MAOB | |
| SCHEMBL8828195 | 0.85 | OPRM1 (0.44) | NOS2MAPTMAOB | |
| SCHEMBL8828318 | 0.83 | DRD3 (0.44) | NOS2LMNAMAOB | |
| SCHEMBL8828417 | 0.83 | L3MBTL1 (0.42) | LMNAMAPTMAOBTP53 | |
| SCHEMBL9156723 | 0.83 | MAOB (0.46) | LMNAMAPTMAOBHTT | |
| SCHEMBL8828168 | 0.83 | DRD3 (0.45) | — | |
| SCHEMBL8828202 | 0.83 | DRD3 (0.41) | MAOB | |
| SCHEMBL9159739 | 0.83 | MAOB (0.42) | MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |