Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | QPCT | Q16769 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235063 | 0.89 | MAPT (0.40) | MAPTCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8828189 | 0.88 | NOS2 (0.42) | NOS2QPCTMAOBALDH1A1POLB | |
| SCHEMBL8828195 | 0.87 | OPRM1 (0.44) | NOS2QPCTMAPTCYP3A4CYP2C9 | |
| SCHEMBL9159790 | 0.87 | NOS2 (0.39) | NOS2QPCTMAPTALDH1A1MEN1 | |
| SCHEMBL9233122 | 0.86 | OPRM1 (0.42) | NOS2QPCTMAPTCYP3A4CYP2C9 | |
| SCHEMBL8828270 | 0.85 | ALDH1A1 (0.39) | NOS2MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8828347 | 0.84 | POLB (0.40) | MAPTCYP3A4CYP2C9CYP2C19MAOB | |
| SCHEMBL9160949 | 0.83 | MAPK1 (0.44) | MAPTCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8828264 | 0.82 | NOS2 (0.39) | NOS2QPCTMAPTCYP3A4CYP2C9 | |
| SCHEMBL9160192 | 0.81 | CYP3A4 (0.38) | MAPTCYP3A4MAOBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | claimed |
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |