Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828233 | 0.87 | OPRM1 (0.47) | MAPK1SMPD1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL9160110 | 0.86 | PTAFR (0.47) | MAPK1SMPD1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL8828201 | 0.83 | NOS2 (0.40) | MAPTCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9235063 | 0.80 | MAPT (0.40) | SMN1; SMN2MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8828139 | 0.79 | ALDH1A1 (0.44) | SMPD1PTAFRALDH1A1MEN1KMT2A | |
| SCHEMBL8828221 | 0.78 | OPRM1 (0.48) | SMN1; SMN2MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9282465 | 0.77 | ALDH1A1 (0.39) | MAPTCYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL9159790 | 0.76 | NOS2 (0.39) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9044237 | 0.75 | OPRM1 (0.44) | MAPK1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL9160567 | 0.75 | PTAFR (0.46) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |