Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.62 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28272519 | 0.92 | DRD2 (0.64) | DRD2DRD3HTR1ACYP2C19HTR3E | |
| SCHEMBL8957716 | 0.88 | DRD2 (0.61) | DRD2DRD3HTR1ACYP2C19HTR3E | |
| SCHEMBL8828472 | 0.87 | ALDH1A1 (0.58) | DRD2DRD3DRD4MAPTALDH1A1 | |
| SCHEMBL8828600 | 0.85 | ADRA1A (0.54) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8828418 | 0.83 | DRD2 (0.47) | DRD2DRD3HTR1ADRD4HRH2 | |
| SCHEMBL8828782 | 0.83 | DRD2 (0.44) | DRD2DRD3HTR1ADRD4MAPT | |
| SCHEMBL8828530 | 0.83 | DRD2 (0.44) | DRD2DRD3HTR1ADRD4ALDH1A1 | |
| SCHEMBL8828496 | 0.83 | DRD2 (0.44) | DRD2DRD3HTR1AHTR6ALDH1A1 | |
| SCHEMBL8828612 | 0.82 | GAA (0.45) | DRD2DRD3HTR1ADRD4MAPT | |
| SCHEMBL8828459 | 0.82 | DRD2 (0.42) | DRD2DRD3HTR1ADRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| US-5503843-A | PATCH HAVING EITHER A LIQUID RESERVOIR OR MONOLITHIC MATRIX CONTAINING A PERMEATION ENHANCER AND 2-PHENYL-3-METHYL-8-(1-(4-(METHOXYPHENYL)PIPERAZIN-1-YL)PROPYLAMINO-4 -CARBONYL-4H-CHROMEN-4-ONE; BENIGN PROSTRATE HYPERPLASIA | FLORA INC. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0343961-B1 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PROD (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5482940-A | OBESITY, ALCOHOLISM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5380725-A | Antipsychotic agents and anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5278160-A | Treating aggressive behavior | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-01-11 | — | — | US | disclosed |
| US-5254552-A | Cognition activators, psychological disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| US-5106849-A | Treating anxiety, depression, psychoses | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-5010078-A | Anxiolytic, antidepressant agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0343961-A2 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-11-29 | — | — | EP | disclosed |