SCHEMBL882949

SCHEMBL882949

C=CCOC(=O)Nc1cccc(C(N)=O)c1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
PARP1 P09874 13/20 0.51
PARP10 Q53GL7 11/20 0.51
PARP15 Q460N3 6/20 0.51
PARP14 Q460N5 4/20 0.51
HPGD P15428 3/20 0.50
RAB9A P51151 2/20 0.48
LMNA P02545 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23201123 0.86 HPGD (0.50) MEN1KMT2AHPGDRAB9ALMNA
SCHEMBL8490672 0.84 HPGD (0.64) MEN1KMT2APARP1PARP10PARP15
SCHEMBL555511 0.84 HPGD (0.48) MEN1KMT2AHPGDRAB9ALMNA
SCHEMBL555091 0.84 HPGD (0.48) MEN1KMT2AHPGDRAB9ALMNA
SCHEMBL1127078 0.83 RAB9A (0.67) MEN1KMT2AHPGDRAB9ALMNA
SCHEMBL20169847 0.81 SMN1; SMN2 (0.65) MEN1KMT2APARP1PARP10PARP15
SCHEMBL11782094 0.81 KMT2A (0.49) MEN1KMT2ARAB9ALMNASMN1; SMN2
SCHEMBL10192014 0.80 HSD17B10 (0.53) MEN1KMT2AHPGDRAB9ALMNA
SCHEMBL832082 0.80 RAB9A (0.64) MEN1KMT2APARP1PARP10PARP15
SCHEMBL29687812 0.80 RAB9A (0.64) MEN1KMT2APARP1PARP10PARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 US disclosed
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 US disclosed
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-06-13 US disclosed
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-06-13 US disclosed
EP-3888632-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS The Brigham and Women's Hospital, Inc. (US) 2021-10-06 EP disclosed
EP-3412279-B1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS BRIGHAM & WOMENS HOSPITAL INC (US) 2021-02-17 EP disclosed
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE GENERAL HOSPITAL CORPORATION 2021-01-14 US disclosed
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2020-06-09 US disclosed
US-9974859-B2 Nanostructured gels capable of controlled release of entrapped agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-22 US disclosed
US-9974859-B2 Nanostructured gels capable of controlled release of entrapped agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-22 US disclosed
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-01-05 US disclosed
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-01-05 US disclosed
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-24 US disclosed
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-24 US disclosed
WO-2012040623-A2 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2012-03-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS MMP2, CEL, LIPA MEN1 3515/4885KMT2A 3895/4885PARP1 2727/4885
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA MEN1 3515/4885KMT2A 3895/4885PARP1 2727/4885
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA MEN1 3515/4885KMT2A 3895/4885PARP1 2727/4885
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS MMP2, MMP1, GUSB MEN1 3859/4885KMT2A 4034/4885PARP1 2651/4885
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA MEN1 3515/4885KMT2A 3895/4885PARP1 2727/4885
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA MEN1 3515/4885KMT2A 3895/4885PARP1 2727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.