Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271637 | 0.85 | NPC1 (0.58) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL4264922 | 0.78 | NPC1 (0.59) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL4271936 | 0.75 | NPC1 (0.55) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL9704244 | 0.75 | NPC1 (0.48) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11781553 | 0.73 | NPC1 (0.57) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL16724449 | 0.71 | P2RY12 (0.51) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL4273262 | 0.71 | ADORA3 (0.53) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL18942952 | 0.71 | ALDH1A1 (0.62) | NPC1ALDH1A1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL14802124 | 0.70 | LTA4H (0.53) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL28166768 | 0.69 | RXRA (0.53) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670526-A | ANTIINFLAMMATORY AGENT, IMMUNOSUPPRESSANT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |