Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10888889 | 0.86 | ELANE (0.56) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7542033 | 0.84 | KDM4E (0.58) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7910478 | 0.82 | ALDH1A1 (0.44) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL1712500 | 0.82 | LMNA (0.47) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL8201911 | 0.81 | SLC6A3 (0.57) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL7608797 | 0.81 | HSD17B10 (0.41) | LMNAKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL30420964 | 0.81 | HSD17B10 (0.41) | LMNAKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL10770649 | 0.79 | ELANE (0.61) | LMNAKDM4EALDH1A1MAPTESR1 | |
| SCHEMBL5708950 | 0.79 | LMNA (0.60) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL12691550 | 0.78 | CTSD (0.45) | SMN1; SMN2KMT2AMAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602115-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| US-5412141-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0544812-B1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | UPJOHN CO (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0544812-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS. | UPJOHN CO (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003451-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1992-03-05 | — | — | WO | disclosed |