Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 5/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | SI | P14410 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8832745 | 0.83 | PTGS1 (0.68) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL8833077 | 0.80 | ABCB1 (0.50) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| Noreugenin SCHEMBL168822 | 0.78 | PTGS2 (0.71) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| Noreugenin SCHEMBL29370130 | 0.78 | PTGS2 (0.71) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL29904992 | 0.75 | POLH (0.71) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL7942485 | 0.73 | KMT2A (0.68) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL504349 | 0.73 | MGAM (0.74) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL21671248 | 0.69 | PTGS1 (0.61) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL3782322 | 0.68 | CLK2 (0.63) | HSD17B10CYP3A4ALDH1A1HPGDTSHR | |
| SCHEMBL1673012 | 0.67 | PTGS1 (0.62) | HSD17B10CYP3A4ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5675023-A | VISION DEFECTS; NERVOUS SYSTEM DISORDERS; COMPLICATIONS OF DIABETES | TSUMURA & CO. (JP) | 1997-10-07 | — | — | US | disclosed |
| US-5627204-A | ENZYME INHIBITORS FOR TREATMENT OF DIABETES | TSUMURA & COMPANY (JP) | 1997-05-06 | — | — | US | disclosed |
| US-5521216-A | TREATING COMPLICATIONS OF DIABETES | TSUMURA & CO. (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5455267-A | For reducing side effects of diabetes | TSUMURA & CO. (JP) | 1995-10-03 | — | — | US | disclosed |
| EP-0605728-A1 | CHROMONE DERIVATIVE AND ALDOSE REDUCTASE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | TSUMURA & CO. (JP) | 1994-07-13 | — | — | EP | disclosed |