Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842827 | 0.83 | NOTUM (0.48) | — | |
| SCHEMBL8842891 | 0.77 | PIN1 (0.47) | MAPK1MAP2K4MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL11007641 | 0.74 | KIF11 (0.47) | KIF11CYP11B2CYP11B1FFAR1 | |
| SCHEMBL10957748 | 0.72 | KIF11 (0.46) | KIF11CYP11B2CYP11B1FFAR1 | |
| SCHEMBL8842823 | 0.72 | RAB9A (0.50) | MAPK1MAP2K4MAPK6MAPKAPK3 | |
| SCHEMBL2118385 | 0.68 | TRPV1 (0.45) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL2120061 | 0.68 | KIF11 (0.45) | KIF11CYP11B2CYP11B1FFAR1 | |
| SCHEMBL21116892 | 0.67 | KIF11 (0.76) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL27651907 | 0.67 | KIF11 (0.49) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL12226968 | 0.66 | KIF11 (0.51) | KIF11CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674887-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0578477-B1 | Treatment of inflammatory bowel disease | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5436258-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0587378-A1 | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5294630-A | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0578477-A1 | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-01-12 | — | — | EP | disclosed |