Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842875 | 0.86 | ADORA2A (0.48) | PIN1KMOPIM1GRK6NOTUM | |
| SCHEMBL23294713 | 0.82 | PIN1 (0.48) | PIN1KMOPIM1GRK6NOTUM | |
| SCHEMBL11073722 | 0.82 | PIN1 (0.46) | PIN1KMOPIM1GRK6NOTUM | |
| SCHEMBL8842823 | 0.79 | RAB9A (0.50) | PIN1MAPK1MAP2K4MAPK6MAPKAPK3 | |
| SCHEMBL8842830 | 0.77 | KIF11 (0.47) | MAPK1MAP2K4MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL8842827 | 0.76 | NOTUM (0.48) | NOTUM | |
| SCHEMBL9403614 | 0.76 | IKBKB (0.46) | PIN1PIM1GRK6NOTUMMAP2K4 | |
| SCHEMBL2860093 | 0.75 | MAP2K4 (0.71) | KMOPIM1MAPK1MAP2K4MAPK6 | |
| SCHEMBL11073721 | 0.74 | MAPT (0.46) | PIN1PIM1NOTUMALDH1A1SMN1; SMN2 | |
| SCHEMBL8843382 | 0.73 | ALDH1A1 (0.53) | PIN1KMOALDH1A1SMN1; SMN2XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674887-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0578477-B1 | Treatment of inflammatory bowel disease | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5436258-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0587378-A1 | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5294630-A | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0578477-A1 | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-01-12 | — | — | EP | disclosed |