Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845774 | 0.84 | MEN1 (0.41) | MAPTKCNJ1KCNH2MEN1KMT2A | |
| SCHEMBL8845414 | 0.81 | KCNJ1 (0.47) | MAPTTHRBKCNJ1KCNH2MEN1 | |
| SCHEMBL8845312 | 0.75 | CHRNB4 (0.43) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8845493 | 0.73 | LOXL2 (0.36) | ALDH1A1LMNAPOLBCYP19A1 | |
| SCHEMBL8845327 | 0.72 | KMT2A (0.42) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL16089350 | 0.70 | VCAM1 (0.61) | MAPTTHRBKCNJ1KCNH2MEN1 | |
| SCHEMBL57257 | 0.70 | VCAM1 (0.61) | MAPTTHRBKCNJ1KCNH2MEN1 | |
| SCHEMBL22495451 | 0.70 | SIRT6 (0.63) | MAPTKCNJ1KCNH2MEN1KMT2A | |
| SCHEMBL8845328 | 0.69 | CYP19A1 (0.44) | MAPTKCNJ1KCNH2MEN1KMT2A | |
| SCHEMBL8845922 | 0.69 | POLB (0.48) | MAPTMEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674886-A | AROMATASE INHIBITOR; BREAST CANCER; UROGENITAL DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-07 | — | — | US | disclosed |