SCHEMBL8846019

SCHEMBL8846019

O=C1c2c(F)c(F)c(F)c(F)c2C(=O)N1CCN1C(=O)c2c(F)c(F)c(F)c(F)c2C1=O

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.33
CRBN Q96SW2 1/20 0.33
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
ATM Q13315 1/20 0.30
ANPEP P15144 1/20 0.30
DPP4 P27487 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18535556 0.85 ALDH1A1 (0.31) TNFCRBNRAB9AANPEPDPP4
SCHEMBL10338047 0.85 KDM4E (0.41) TNFCRBNNPC1RAB9A
SCHEMBL23027211 0.82 ALDH1A1 (0.48) NPC1RAB9A
SCHEMBL13187754 0.80 PARK7 (0.44)
SCHEMBL6955706 0.79 TNF (0.32) TNFCRBN
SCHEMBL7567498 0.79 F2 (0.43) TNFCRBNATMANPEPDPP4
SCHEMBL8846154 0.77 MEN1 (0.31) NPC1RAB9A
SCHEMBL3621290 0.74 TNF (0.34) TNFCRBNNPC1RAB9AANPEP
SCHEMBL10670259 0.74 CASP3 (0.43)
SCHEMBL22835537 0.73 CA1 (0.47) RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150219846-A1 Method for Manufacturing Polymer Optical Waveguide NITTO DENKO CORPORATION (JP) 2015-08-06 US disclosed
EP-2894499-A1 METHOD FOR MANUFACTURING POLYMER OPTICAL WAVEGUIDE Nitto Denko Corporation (JP) 2015-07-15 EP disclosed
EP-0563986-B1 Process for selective hydrodefluorination OCCIDENTAL CHEM CO (US) 1997-09-03 EP disclosed
US-5294738-A Hydrolysis of imide and hydrodefluorination OCCIDENTAL CHEMICAL CORPORATION (US) 1994-03-15 US disclosed
EP-0563986-A2 Process for selective hydrodefluorination Occidental Chemical Corporation (US) 1993-10-06 EP disclosed