Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25327524 | 0.85 | NAPRT (0.56) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL13028710 | 0.81 | NAPRT (0.60) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL2937504 | 0.79 | NAPRT (0.58) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL5321257 | 0.78 | CES1 (0.47) | KCNQ3KCNQ2HDAC6CES1L3MBTL1 | |
| SCHEMBL10575120 | 0.78 | NAPRT (0.67) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL25177793 | 0.78 | JUN (0.47) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL8099539 | 0.78 | PLOD2 (0.56) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL17801 | 0.77 | NAPRT (0.72) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL29760376 | 0.77 | NAPRT (0.72) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL7440808 | 0.77 | NAPRT (0.72) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719394-A2 | INHIBITORS OF TYK2 | Atomwise Inc. (US) | 2026-04-08 | — | — | EP | disclosed |
| US-20260048051-A1 | TREATMENT OF INFLAMMATORY BOWEL DISEASE | ATOMWISE INC (US) | 2026-02-19 | — | — | US | disclosed |
| US-12358904-B2 | Inhibitors of TYK2 | Atomwise Inc. (US) | 2025-07-15 | — | — | US | disclosed |
| US-20240425484-A1 | INHIBITORS OF TYK2 | Atomwise Inc. | 2024-12-26 | — | — | US | disclosed |
| US-20240417396-A1 | INHIBITORS OF TYK2 | Atomwise Inc. | 2024-12-19 | — | — | US | disclosed |
| WO-2024250010-A2 | INHIBITORS OF TYK2 | Atomwise Inc. (US) | 2024-12-05 | — | — | WO | disclosed |
| US-20200181134-A1 | Antiparasitic Compounds | CAMBREX CHARLES CITY, INC. | 2020-06-11 | — | — | US | disclosed |
| EP-2678329-B1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-11-18 | — | — | EP | disclosed |
| US-8889704-B2 | Triazolopyridine compounds as PIM kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140005213-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-01-02 | — | — | US | disclosed |
| EP-2678329-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012154274-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-15 | — | — | WO | disclosed |
| EP-0623103-B1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL KETONES | HOECHST SCHERING AGREVO GMBH (DE) | 1997-09-03 | — | — | EP | disclosed |
| US-5608062-A | Process for preparing trifluoromethyl ketones | HOECHST SCHERING AGREVO GMBH (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0623103-A1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL KETONES. | HOECHST SCHERING AGREVO GMBH (DE) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014054-A1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL KETONES | HOECHST SCHERING AGREVO GMBH (DE) | 1993-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240417396-A1 | INHIBITORS OF TYK2 | TYK2, LCK, JAK2 | NAPRT 2630/4885KCNQ3 1203/4885KCNQ2 1021/4885 |
| US-20260048051-A1 | TREATMENT OF INFLAMMATORY BOWEL DISEASE | TYK2, FRK, DYRK2 | NAPRT 4105/4885KCNQ3 2380/4885KCNQ2 2838/4885 |
| US-20140005213-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | NAPRT 3920/4885KCNQ3 634/4885KCNQ2 653/4885 |
| US-12358904-B2 | Inhibitors of TYK2 | TYK2, LCK, JAK2 | NAPRT 2630/4885KCNQ3 1203/4885KCNQ2 1021/4885 |
| US-20200181134-A1 | Antiparasitic Compounds | ACHE, DDT, NISCH | NAPRT 3056/4885KCNQ3 1141/4885KCNQ2 1098/4885 |
| US-20240425484-A1 | INHIBITORS OF TYK2 | TYK2, LCK, JAK2 | NAPRT 2630/4885KCNQ3 1203/4885KCNQ2 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.