Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855376 | 0.81 | SRD5A2 (0.35) | EP300HIF1AEPAS1 | |
| SCHEMBL12260908 | 0.75 | AR (0.54) | HIF1AEPAS1 | |
| SCHEMBL29553636 | 0.75 | AR (0.54) | HIF1AEPAS1 | |
| SCHEMBL29552794 | 0.74 | HIF1A (0.35) | EP300HIF1AEPAS1 | |
| SCHEMBL9359973 | 0.73 | CYP3A4 (0.50) | EP300HIF1AEPAS1 | |
| SCHEMBL15732245 | 0.72 | EP300 (0.46) | EP300HIF1AEPAS1 | |
| SCHEMBL9359538 | 0.70 | KARS1 (0.34) | EP300HIF1AEPAS1 | |
| SCHEMBL8855131 | 0.70 | KARS1 (0.51) | EP300 | |
| SCHEMBL8855191 | 0.67 | KARS1 (0.53) | — | |
| SCHEMBL9360372 | 0.67 | POLA1 (0.44) | EP300HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654343-A | NITRIC OXIDE SYNTHESIS INHIBITOR; TREATING ENDOTOXIC SHOCK | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0676196-A1 | NITROGEN MONOXIDE SYNTHESIS INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-11 | — | — | EP | disclosed |