Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 7/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856425 | 0.88 | GCGR (0.37) | TP53SMN1; SMN2GCGRGIPRALDH1A1 | |
| SCHEMBL8856113 | 0.85 | UBE2M (0.40) | SMN1; SMN2ALDH1A1UBE2MDCUN1D1 | |
| SCHEMBL8817855 | 0.84 | ALDH1A1 (0.44) | TP53ALDH1A1ALOX15TSHRHSD17B10 | |
| SCHEMBL9056568 | 0.84 | KMT2A (0.41) | TP53SMN1; SMN2ALDH1A1ALOX15TSHR | |
| SCHEMBL8808308 | 0.75 | ROCK2 (0.40) | TP53SMN1; SMN2ALDH1A1HSD17B10UBE2M | |
| SCHEMBL8344843 | 0.75 | KDM4E (0.42) | TP53SMN1; SMN2ALDH1A1HSD17B10UBE2M | |
| SCHEMBL8856219 | 0.73 | UBE2M (0.39) | UBE2MDCUN1D1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8808860 | 0.73 | USP2 (0.43) | TP53ALDH1A1HSD17B10UBE2MDCUN1D1 | |
| SCHEMBL8341852 | 0.73 | UBE2M (0.42) | GCGRALDH1A1UBE2MDCUN1D1KDM4E | |
| SCHEMBL8338160 | 0.73 | SLC6A2 (0.44) | SMN1; SMN2ALDH1A1UBE2MDCUN1D1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |