Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856367 | 0.88 | ALDH1A1 (0.35) | LMNAMAPTHTT | |
| SCHEMBL8856232 | 0.84 | GPR84 (0.32) | LMNAMAPT | |
| SCHEMBL8856471 | 0.84 | GPR84 (0.36) | LMNAMAPTHTT | |
| SCHEMBL8856532 | 0.79 | SOAT2 (0.34) | LMNAMAPTHTTNAAA | |
| SCHEMBL8856254 | 0.77 | ALDH1A1 (0.36) | LMNAMAPTHTT | |
| SCHEMBL8856168 | 0.74 | GPR84 (0.32) | — | |
| SCHEMBL8856571 | 0.71 | CDC7 (0.36) | LMNAMAPT | |
| SCHEMBL8856252 | 0.69 | CYP1A2 (0.35) | LMNA | |
| SCHEMBL8856140 | 0.69 | PAK1 (0.32) | LMNA | |
| SCHEMBL8323237 | 0.67 | LMNA (0.31) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |