Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.34 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856377 | 0.89 | MMP9 (0.38) | MMP9MMP13ADAM17LMNAMAPT | |
| SCHEMBL8856240 | 0.86 | SOAT2 (0.36) | SOAT2ACAT1SOAT1MMP9MMP13 | |
| SCHEMBL8856473 | 0.86 | GPR84 (0.38) | SOAT2ACAT1SOAT1MMP9MMP13 | |
| SCHEMBL8856260 | 0.79 | GAA (0.37) | SOAT2ACAT1SOAT1MAPT | |
| SCHEMBL8856530 | 0.79 | LMNA (0.31) | LMNAMAPTHTTNAAA | |
| SCHEMBL8856180 | 0.77 | GPR84 (0.36) | SOAT2ACAT1SOAT1MMP9MMP13 | |
| SCHEMBL8856685 | 0.77 | TRPV1 (0.38) | SOAT2ACAT1SOAT1LMNAHTT | |
| SCHEMBL8856150 | 0.74 | ALDH1A1 (0.44) | SOAT2ACAT1SOAT1LMNAHTT | |
| SCHEMBL8856574 | 0.74 | MMP9 (0.38) | MMP9MMP13ADAM17 | |
| SCHEMBL8856190 | 0.73 | PYGL (0.42) | SOAT2ACAT1SOAT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |