Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3355751 | 0.83 | PNMT (0.38) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL7052931 | 0.73 | PNMT (0.39) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL524602 | 0.71 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL30103334 | 0.71 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL7057184 | 0.70 | PNMT (0.36) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL17845923 | 0.69 | PNMT (0.46) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL27885618 | 0.69 | PNMT (0.57) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL2877998 | 0.69 | PNMT (0.61) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL8468716 | 0.69 | PNMT (0.49) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL1480277 | 0.68 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5635573-A | ADDITION POLYMERIZATION USING A CYCLOPENTADIENYL METALLOCENE CATALYST SYSTEM BASED ON TRANSITION METAL COMPOUNDS FROM GROUP 4 OF THE PERIODIC TABLE | EXXON CHEMICAL PATENTS INC. (US) | 1997-06-03 | — | — | US | disclosed |