Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 12/20 | 0.58 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858403 | 0.92 | PTGIR (0.61) | PTGIRPTGDRSIGMAR1TSHRMAPT | |
| SCHEMBL9049336 | 0.84 | PTGIR (0.39) | PTGIRPTGDRTSHRMAPTTDP1 | |
| SCHEMBL8858416 | 0.83 | PTGIR (0.57) | PTGIRPTGDRSIGMAR1MAPTLMNA | |
| SCHEMBL9568057 | 0.82 | ALDH1A1 (0.39) | PTGIRSIGMAR1TSHRMAPTTDP1 | |
| SCHEMBL8858459 | 0.81 | PTGIR (0.50) | PTGIRPTGDRSIGMAR1MAPTUSP2 | |
| SCHEMBL9049403 | 0.79 | PTGIR (0.45) | PTGIRPTGDRSIGMAR1TSHR | |
| SCHEMBL8858468 | 0.78 | PTGIR (0.40) | PTGIRPTGDRTSHRMAPTUSP2 | |
| SCHEMBL8858472 | 0.78 | PTGIR (0.40) | PTGIRPTGDRTSHRMAPTUSP2 | |
| SCHEMBL9014200 | 0.76 | PTGIR (0.55) | PTGIRPTGDRSIGMAR1DDB1CRBN | |
| SCHEMBL9049399 | 0.75 | KMT2A (0.41) | PTGIRPTGDRTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542203-B1 | Fused benzeneoxyacetic acid derivatives as PGl2 receptor agonists | ONO PHARMACEUTICAL CO (JP) | 1996-07-03 | — | — | EP | claimed |
| US-5344836-A | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | claimed |
| US-5596009-A | TREATMENT OF THROMBOSIS, ATHERIOSCLEROSIS, ANTIISCHEMIC AGENTS, ANTIULCER AGENTS OR HYPOTENSIVE AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-01-21 | — | — | US | disclosed |
| EP-0542203-B1 | Fused benzeneoxyacetic acid derivatives as PGl2 receptor agonists | ONO PHARMACEUTICAL CO (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5344836-A | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |