Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860537 | 0.96 | PTGS1 (0.64) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| SCHEMBL8860230 | 0.95 | XDH (0.67) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| Quinquangulin SCHEMBL4742445 | 0.86 | PTGS1 (0.64) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| Ustilaginoidin A SCHEMBL3119631 | 0.82 | PTGS1 (0.62) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| SCHEMBL8860458 | 0.80 | PTGS1 (0.48) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| Rubrofusarin B SCHEMBL29779134 | 0.76 | XDH (1.00) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| Rubrofusarin B SCHEMBL16227248 | 0.76 | XDH (1.00) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| Aurasperone A SCHEMBL29779131 | 0.75 | XDH (0.80) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| SCHEMBL29403680 | 0.74 | PTGS1 (0.80) | XDHPTGS1PTGS2HIF1AEPAS1 | |
| SCHEMBL15060666 | 0.74 | XDH (0.79) | XDHPTGS1PTGS2HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614642-A | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof | SUGEN INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5602171-A | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof | SUGEN INC. (US) | 1997-02-11 | — | — | US | disclosed |