Aurasperone A

Aurasperone A

SCHEMBL29779131

COc1cc(OC)c2c(O)c3c(=O)cc(C)oc3c(-c3c(OC)cc4cc5oc(C)cc(=O)c5c(O)c4c3OC)c2c1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.80
PTGS1 P23219 8/20 0.51
PTGS2 P35354 8/20 0.51
HIF1A Q16665 3/20 0.45
EPAS1 Q99814 3/20 0.45
EPHX2 P34913 1/20 0.43
KLK7 P49862 1/20 0.41
KLK5 Q9Y337 1/20 0.41
ABCB1 P08183 1/20 0.40
CYP1A1 P04798 1/20 0.40
CYP3A4 P08684 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
THRB P10828 1/20 0.40
HPGD P15428 1/20 0.40
MAPK1 P28482 1/20 0.40
ABCG2 Q9UNQ0 1/20 0.39
FLT3 P36888 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Asperpyrone C SCHEMBL29779200 0.94 XDH (0.73) XDHPTGS1PTGS2HIF1AEPAS1
Fonsecinone A SCHEMBL29779161 0.89 XDH (1.00) XDHPTGS1PTGS2HIF1AEPAS1
Asperpyrone A SCHEMBL29779212 0.85 XDH (0.93) XDHPTGS1PTGS2HIF1AEPAS1
Rubrofusarin B SCHEMBL16227248 0.80 XDH (1.00) XDHPTGS1PTGS2HIF1AEPAS1
Rubrofusarin B SCHEMBL29779134 0.80 XDH (1.00) XDHPTGS1PTGS2HIF1AEPAS1
SCHEMBL8860230 0.79 XDH (0.67) XDHPTGS1PTGS2HIF1AEPAS1
SCHEMBL21638079 0.77 XDH (0.64) XDHPTGS1PTGS2HIF1AEPAS1
SCHEMBL29779171 0.77 XDH (0.64) XDHPTGS1PTGS2HIF1AEPAS1
SCHEMBL8860175 0.75 XDH (0.61) XDHPTGS1PTGS2HIF1AEPAS1
SCHEMBL8860356 0.74 XDH (0.74) XDHPTGS1PTGS2HIF1AEPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250360073-A1 SOLUBILIZING PIGMENTS EXTRACTED FROM FUNGI FOR APPLICATIONS SUCH AS COSMETIC PRODUCTS ADLER JESSE (US) 2025-11-27 US disclosed
CN-118562908-A Preparation method and application of benzopyrone compound in Kandelia candel endophytic fungi 海南师范大学 2024-08-30 CN disclosed
CN-114848628-B Application of naphtho gamma-pyrone compounds in preparation of anti-helicobacter pylori medicines or health care products 暨南大学 2023-07-25 CN disclosed
CN-114848628-A Application of naphtho-gamma-pyrone compounds in preparation of anti-helicobacter pylori medicines or prevention health-care products 暨南大学 2022-08-05 CN disclosed
CN-113444644-B Application of naphtho-gamma-pyrone compounds in preparation of anti-helicobacter pylori medicines or prevention health-care products 暨南大学 2022-07-19 CN disclosed