Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | PDE1A | P54750 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8928281 | 0.99 | POLB (0.48) | POLBMAPK1SMN1; SMN2METRPS6KA3 | |
| SCHEMBL8928204 | 0.90 | CACNA1C (0.40) | POLBMAPK1SMN1; SMN2IDO1PDE2A | |
| SCHEMBL8928246 | 0.86 | IDO1 (0.44) | METIDO1PDE2APDE1APDE1B | |
| SCHEMBL8928277 | 0.85 | CACNA1C (0.54) | ALDH1A1MAPTCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8928253 | 0.85 | PDE3B (0.52) | POLBMAPK1SMN1; SMN2METRPS6KA3 | |
| SCHEMBL8928241 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDCASP1 | |
| SCHEMBL8928269 | 0.79 | SMN1; SMN2 (0.46) | POLBMAPK1SMN1; SMN2METRPS6KA3 | |
| SCHEMBL7268117 | 0.79 | IDO1 (0.47) | IDO1CYP3A4 | |
| SCHEMBL10475638 | 0.76 | CACNA1F (0.50) | POLBMAPK1SMN1; SMN2PDE1CKDM4E | |
| SCHEMBL8781999 | 0.75 | IDO1 (0.43) | IDO1CYP3A4F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | claimed |
| JP-9040668-A | — | — | None | — | — | JP | disclosed |
| JP-H0940668-A | DIHYDROPYRIDINE AND PYRIDINE DERIVATIVE AND THEIR PRODUCTION | PHARMACIA SPA | 1997-02-10 | — | — | JP | disclosed |
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | disclosed |