Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928277 | 0.88 | CACNA1C (0.54) | NR3C2ADORA3CACNA1CCACNA1FCACNA1D | |
| SCHEMBL8928204 | 0.87 | CACNA1C (0.40) | KDM4EPDE4DCACNA1CLMNAMAPT | |
| SCHEMBL8860432 | 0.84 | POLB (0.49) | KDM4ECYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8928281 | 0.84 | POLB (0.48) | KDM4ECYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10475638 | 0.82 | CACNA1F (0.50) | KDM4ENR3C2ADORA3CACNA1CCACNA1F | |
| SCHEMBL30357940 | 0.80 | CACNA1F (0.54) | KDM4EADORA3CACNA1CCACNA1FCACNA1D | |
| SCHEMBL7269131 | 0.80 | CACNA1F (0.54) | KDM4EADORA3CACNA1CCACNA1FCACNA1D | |
| SCHEMBL7268117 | 0.78 | IDO1 (0.47) | PDE4DCYP3A4 | |
| SCHEMBL10475641 | 0.78 | ADORA3 (0.47) | NR3C2ADORA3CACNA1CCACNA1FCACNA1D | |
| SCHEMBL7277695 | 0.78 | CACNA1C (0.48) | KDM4EADORA3CACNA1CCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | claimed |
| EP-0755931-A1 | Dihydropyridine and pyridine derivatives and process for their preparation | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-29 | — | — | EP | disclosed |