Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761654 | 0.83 | CYP2D6 (0.36) | LMNASMN1; SMN2L3MBTL1CYP2D6MEN1 | |
| SCHEMBL30702419 | 0.81 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1BCHEPOLB | |
| SCHEMBL1046284 | 0.81 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1BCHEPOLB | |
| SCHEMBL16195480 | 0.80 | EP300 (0.35) | LMNAALDH1A1KDM4EMAPTHTT | |
| SCHEMBL27374131 | 0.79 | HTT (0.40) | LMNAALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL10886630 | 0.78 | L3MBTL1 (0.39) | LMNAALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL28522891 | 0.75 | MAPT (0.37) | LMNAALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL10589294 | 0.74 | BRD4 (0.32) | LMNAALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL2909081 | 0.74 | CYP24A1 (0.42) | LMNACYP2D6GSK3B | |
| SCHEMBL8204450 | 0.73 | EP300 (0.34) | LMNAALDH1A1KDM4ETDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112433285-A | Absorption type narrow-band filter | 长春理工大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-101394830-A | Cosmetic agents comprising purine and/or purine derivatives I | HENKEL KGAA (DE) | 2009-03-25 | — | — | CN | disclosed |
| US-5599825-A | ANTITUMOR AGENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1997-02-04 | — | — | US | disclosed |
| CN-1043797-A | The visible sensitizers that is used for photopolymerizable composition | DU PONT (US) | 1990-07-11 | — | — | CN | disclosed |