Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8861416 | 0.83 | LMNA (0.37) | CYP2D6RECQLLMNATSHRKMT2A | |
| SCHEMBL27374131 | 0.71 | HTT (0.40) | CYP2D6LMNAKMT2AGAASMN1; SMN2 | |
| SCHEMBL10589294 | 0.71 | BRD4 (0.32) | CYP2D6LMNATSHRKMT2AGAA | |
| Alcohol SCHEMBL282126 | 0.68 | GAA (0.52) | CYP2D6RECQLLMNATSHRKMT2A | |
| SCHEMBL11699608 | 0.66 | ALDH1A1 (0.43) | CYP2D6LMNATSHRGAASMN1; SMN2 | |
| SCHEMBL11699615 | 0.66 | ALDH1A1 (0.43) | CYP2D6LMNATSHRGAASMN1; SMN2 | |
| SCHEMBL7247849 | 0.66 | ACHE (0.54) | LMNAKMT2ATP53PAX8MEN1 | |
| Alcohol SCHEMBL416962 | 0.66 | ALDH1A1 (0.50) | CYP2D6RECQLLMNATSHRKMT2A | |
| Alcohol SCHEMBL21924395 | 0.66 | ALDH1A1 (0.50) | CYP2D6RECQLLMNATSHRKMT2A | |
| Alcohol SCHEMBL28115493 | 0.66 | ALDH1A1 (0.50) | CYP2D6RECQLLMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545380-B1 | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORP (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5254455-A | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0545380-A1 | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |