Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11589756 | 0.81 | HSD17B1 (0.39) | ALDH1A1CA1CA2LMNACA12 | |
| SCHEMBL31150397 | 0.81 | HSD17B1 (0.39) | ALDH1A1CA1CA2LMNACA12 | |
| SCHEMBL3790406 | 0.79 | VRK1 (0.34) | ALDH1A1LMNAKDM4EGAAMAPT | |
| SCHEMBL11796078 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EGAAMAPT | |
| SCHEMBL3005284 | 0.75 | ALDH1A1 (0.48) | ALDH1A1CA1CA2LMNAKDM4E | |
| SCHEMBL5509678 | 0.75 | CES2 (0.38) | CA1CA2CA12CA7KDM4E | |
| SCHEMBL2396959 | 0.75 | CA1 (0.40) | CA1CA2CA12CA7CA13 | |
| SCHEMBL998262 | 0.75 | ALDH1A1 (0.38) | ALDH1A1CA1CA2LMNACA12 | |
| SCHEMBL30367972 | 0.75 | CA1 (0.40) | CA1CA2CA12CA7CA13 | |
| SCHEMBL78211 | 0.74 | CA1 (0.43) | CA1CA2CA12CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624924-A | Quinobenzothiazine antineoplastic agents | ABBOTT LABORATORIES (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0608215-A1 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5318965-A | Administering to treat leukemia, melanoma, carcinoma of lung, colon, ovaries | ABBOTT LABORATORIES (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0608215-A4 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS. | ABBOTT LAB (US) | 1993-11-11 | — | — | EP | disclosed |
| WO-1993016702-A1 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1993-09-02 | — | — | WO | disclosed |
| WO-1992003136-A1 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |