SCHEMBL998262

SCHEMBL998262

Nc1cc(F)c(F)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.37
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA7 P43166 2/20 0.35
CA13 Q8N1Q1 1/20 0.35
PTK2 Q05397 1/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
HDAC1 Q13547 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
CA4 P22748 1/20 0.30
CA6 P23280 1/20 0.30
CA5A P35218 1/20 0.30
CA9 Q16790 1/20 0.30
CA14 Q9ULX7 1/20 0.30
CA5B Q9Y2D0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5507622 0.83 PTK2 (0.50) ALDH1A1PTK2HDAC1HDAC6
SCHEMBL29690296 0.79 ALDH1A1 (0.36) ALDH1A1LMNACA12CA1CA2
SCHEMBL5513285 0.79 ALDH1A1 (0.36) ALDH1A1CA1CA2PTK2HDAC1
SCHEMBL13385877 0.79 ALDH1A1 (0.36) ALDH1A1PTK2
SCHEMBL30688718 0.79 ALDH1A1 (0.36) ALDH1A1CA1CA2PTK2HDAC1
SCHEMBL899953 0.79 ALDH1A1 (0.36) ALDH1A1LMNACA12CA1CA2
SCHEMBL1462129 0.79 ALDH1A1 (0.36) ALDH1A1LMNACA12CA1CA2
SCHEMBL31150397 0.77 HSD17B1 (0.39) ALDH1A1LMNACA12CA1CA2
SCHEMBL11589756 0.77 HSD17B1 (0.39) ALDH1A1LMNACA12CA1CA2
Hydrazine SCHEMBL27591097 0.76 CA1 (0.46) ALDH1A1LMNACA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118183708-A Method for preparing fluorocarbon material by using fluorine-containing polymer 重庆大学锂电及新材料遂宁研究院 2024-06-14 CN claimed
CN-114349707-B N-substituted urea compound and preparation method and application thereof 中国医学科学院医药生物技术研究所 2024-01-09 CN claimed
CN-103539942-B A kind of preparation method of poly-2,3,5,6-tetrafluoroaniline nanostructure Shanghai National Engineering Research Center for Nanotechnology Co., Ltd. (CN) 2016-01-20 CN claimed
JP-2306945-A None JP disclosed
JP-10182563-A None JP disclosed
US-20260076918-A1 HETEROTELECHELIC COMPOUNDS KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION (JP) 2026-03-19 US disclosed
EP-4688775-A1 SUBSTITUTED SULTAM COMPOUND DERIVATIVES AND THEIR PHARMACEUTICAL USE Avelos Therapeutics Inc. (KR) 2026-02-11 EP disclosed
EP-4631948-A1 NOVEL TRICYCLIC COMPOUND AS KRAS G12D INHIBITOR, AND USE THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2025-10-15 EP disclosed
US-12195473-B2 KRAS mutant protein inhibitors JACOBIO PHARMACEUTICALS CO., LTD (CN) 2025-01-14 US disclosed
WO-2024205311-A1 SUBSTITUTED SULTAM COMPOUND DERIVATIVES AND THEIR PHARMACEUTICAL USE AVELOS THERAPEUTICS INC. (KR) 2024-10-03 WO disclosed
CN-115650925-B Triazole alcohol derivative and preparation method and application thereof 中国人民解放军海军军医大学 2024-09-24 CN disclosed
EP-0332033-A2 N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives BAYER AG (DE) 1989-09-13 EP disclosed
EP-0197280-B1 BENZOYL UREAS BAYER AG (DE) 1989-06-07 EP disclosed
EP-0230053-A2 7-(Substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids AMERICAN CYANAMID COMPANY (US) 1987-07-29 EP disclosed
EP-0197280-A2 Benzoyl ureas BAYER AG (DE) 1986-10-15 EP disclosed
US-4517130-A Substituted amino acid process ZOECON CORPORATION (US) 1985-05-14 US disclosed
EP-0035084-B1 SUBSTITUTED N-FLUORPHENYL-N'-HALOGEN BENZOYL UREAS, PROCESS FOR THEIR PREPRATION, COMPOSITIONS CONTAINING THEM AND THEIR USE IN COMBATING PESTS CIBA-GEIGY AG (CH) 1983-08-31 EP disclosed
EP-0053011-A1 New herbicidal nicotinamide derivatives MAY & BAKER LIMITED (GB) 1982-06-02 EP disclosed
US-4310548-A Pesticidal N-tetrafluorophenyl-N'-benzoyl ureas CIBA-GEIGY CORPORATION (US) 1982-01-12 US disclosed
EP-0035084-A1 Substituted N-fluorphenyl-N'-halogen benzoyl ureas, process for their prepration, compositions containing them and their use in combating pests CIBA-GEIGY AG (CH) 1981-09-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260076918-A1 HETEROTELECHELIC COMPOUNDS LDLR, MSR1, LPAR2 ALDH1A1 2293/4885LMNA 1293/4885CA12 2655/4885
US-12195473-B2 KRAS mutant protein inhibitors KRAS, NRAS, APC ALDH1A1 3978/4885LMNA 3922/4885CA12 4318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.