Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8681907 | 0.81 | DRD2 (0.68) | KDM4EKMT2AGAAMAPTHTT | |
| SCHEMBL8077800 | 0.81 | PARP1 (0.54) | KDM4EKMT2AGAAMAPTHTT | |
| SCHEMBL8875223 | 0.77 | PARP1 (0.58) | KDM4EKMT2AGAAMAPTHTT | |
| SCHEMBL6345975 | 0.76 | SIGMAR1 (0.54) | KMT2AALDH1A1DRD2IL4I1MEN1 | |
| SCHEMBL8875085 | 0.75 | DRD4 (0.53) | KDM4EMAPTHTTALDH1A1DRD2 | |
| SCHEMBL8873570 | 0.74 | KDR (0.45) | KDM4EALDH1A1HSD17B10DRD2DRD4 | |
| SCHEMBL8874246 | 0.73 | KDR (0.45) | KDM4EMAPTHTTALDH1A1HSD17B10 | |
| SCHEMBL8875278 | 0.72 | DRD2 (0.49) | KDM4EKMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8874059 | 0.72 | DRD2 (0.49) | KDM4EKMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8874997 | 0.72 | DRD4 (0.57) | KDM4EKMT2AGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607946-A | Quinolone derivatives as dopamine D4 ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-04 | — | — | US | disclosed |