Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876175 | 0.88 | ALOX15 (0.58) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL10486563 | 0.79 | ALOX15 (0.70) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL30903607 | 0.78 | ALOX15 (0.60) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL28576970 | 0.78 | ALOX15 (0.60) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL10547068 | 0.77 | HNF4A (0.50) | ALOX15ALOX12ALDH1A1KDM4ENPC1 | |
| SCHEMBL27924239 | 0.76 | ALOX15 (0.57) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL27555045 | 0.75 | ALOX15 (0.57) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL8876237 | 0.74 | ALOX15 (0.55) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| Sulfuric Acid SCHEMBL21465852 | 0.73 | ALOX15 (0.51) | ALOX15ALOX12PIK3CAALDH1A1KDM4E | |
| SCHEMBL30937511 | 0.72 | ALOX15 (0.54) | ALOX15ALOX12ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | disclosed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | disclosed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | disclosed |