Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.57 |
| ▸ | HTR1B | P28222 | 9/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879616 | 0.92 | SLC6A4 (0.55) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8870158 | 0.88 | HTR7 (0.55) | HTR1DHTR1BDRD2CHRM2HTR1A | |
| SCHEMBL8871803 | 0.87 | HTR1A (0.58) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8556222 | 0.86 | HTR7 (0.62) | HTR1DHTR1BDRD2CHRM2HTR1A | |
| SCHEMBL8553950 | 0.85 | ADRA2A (0.61) | HTR1AHTR7 | |
| SCHEMBL27431034 | 0.84 | HTR1A (0.57) | HTR1DHTR1BDRD2CHRM2HTR1A | |
| SCHEMBL8871079 | 0.84 | HTR1A (0.63) | DRD2SLC6A4HTR1AHTR2AHTR7 | |
| SCHEMBL8554898 | 0.84 | HTR1A (0.63) | DRD2SLC6A4HTR1AHTR2AHTR7 | |
| SCHEMBL8553791 | 0.83 | HTR1A (0.59) | DRD2SLC6A4HTR1AHTR2AHTR7 | |
| SCHEMBL8555534 | 0.82 | HTR1A (0.59) | HTR1ACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |