Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 10/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR1B | P28222 | 7/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877234 | 0.92 | HTR1D (0.57) | SLC6A4HTR1DDRD2HTR1BCHRM2 | |
| SCHEMBL8877925 | 0.82 | SLC6A4 (0.60) | SLC6A4ADRA1DDRD2HTR2AHTR7 | |
| SCHEMBL8870158 | 0.80 | HTR7 (0.55) | HTR1DDRD2HTR1BCHRM2HTR7 | |
| SCHEMBL1173868 | 0.80 | NPC1 (0.54) | — | |
| SCHEMBL8871803 | 0.80 | HTR1A (0.58) | SLC6A4ADRA1DHTR1DDRD2HTR1B | |
| SCHEMBL51234 | 0.79 | NPC1 (0.53) | CCR2 | |
| SCHEMBL8555534 | 0.79 | HTR1A (0.59) | ADRA1DCCR2 | |
| SCHEMBL8556222 | 0.79 | HTR7 (0.62) | ADRA1DHTR1DDRD2HTR1BCHRM2 | |
| SCHEMBL8876794 | 0.79 | SLC6A4 (0.64) | SLC6A4ADRA1DDRD2 | |
| SCHEMBL8877539 | 0.79 | ADRA1D (0.79) | SLC6A4ADRA1DHTR1DDRD2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |