Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812186 | 0.80 | TDP1 (0.36) | TDP1TP53KDM4EMMP2THRB | |
| SCHEMBL3298772 | 0.78 | — | — | |
| SCHEMBL2298737 | 0.75 | — | — | |
| SCHEMBL5880403 | 0.73 | LPAR3 (0.50) | — | |
| Ethylene Glycol SCHEMBL19617113 | 0.73 | PPARD (0.36) | TDP1TP53ALDH1A1 | |
| SCHEMBL8022721 | 0.73 | — | — | |
| SCHEMBL533763 | 0.72 | FDPS (0.44) | TDP1KDM4EMMP2THRBMAPK1 | |
| SCHEMBL9422627 | 0.71 | — | — | |
| SCHEMBL2782188 | 0.71 | TP53 (0.36) | TDP1TP53FDPS | |
| SCHEMBL4995915 | 0.71 | KDM4E (0.31) | TDP1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058031-B2 | Labeled nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110059450-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-03-10 | — | — | US | disclosed |
| US-7777013-B2 | Labeled nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090018324-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-7405281-B2 | Fluorescent nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1937702-A2 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | Pacific Biosciences of California, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041342-A2 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072196-A1 | Fluorescent nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072196-A1 | Fluorescent nucleotide analogs and uses therefor | DNTT, POLRMT, RNGTT | TDP1 242/4885TP53 1331/4885KDM4E 4803/4885 |
| US-20090018324-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | POLRMT, DNTT, NUDT1 | TDP1 227/4885TP53 1517/4885KDM4E 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.