Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | SNCA | P37840 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175562 | 0.89 | NOX1 (0.68) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL3176131 | 0.86 | NOX1 (0.68) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL9007338 | 0.83 | MAPT (0.68) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL4080414 | 0.82 | NOX1 (1.00) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL29636455 | 0.79 | SNCA (1.00) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL3489840 | 0.79 | SNCA (1.00) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL11386797 | 0.79 | TP53 (0.64) | MAPTGAASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL8988 | 0.78 | L3MBTL1 (1.00) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL10669023 | 0.78 | L3MBTL1 (0.68) | MAPTGAASMN1; SMN2L3MBTL1NOX1 | |
| SCHEMBL10671474 | 0.77 | L3MBTL1 (0.54) | MAPTGAASMN1; SMN2L3MBTL1NOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728735-A | LIPOXYGENASE INHIBITORS | MERCK & CO., INC. (US) | 1988-03-01 | — | — | US | claimed |
| US-5607929-A | Antiviral dibenzothiazepinone derivatives | GLAXO WELLCOME INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5589474-A | Dibenzothiazepinthione as antiviral agents | GLAXO WELLCOME INC. (US) | 1996-12-31 | — | — | US | disclosed |
| EP-0583317-A1 | DIBENZOTHIAZEPINTHIONE AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992019607-A1 | DIBENZOTHIAZEPINTHIONE AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-11-12 | — | — | WO | disclosed |
| US-4728735-A | LIPOXYGENASE INHIBITORS | MERCK & CO., INC. (US) | 1988-03-01 | — | — | US | disclosed |