Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175562 | 0.89 | NOX1 (0.68) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL8879433 | 0.86 | MAPT (0.68) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL239600 | 0.82 | NOX1 (1.00) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| Phenothiazine SCHEMBL9074312 | 0.82 | NOX1 (1.00) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL7710864 | 0.81 | L3MBTL1 (0.68) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| Benzene SCHEMBL29242182 | 0.80 | NOX1 (0.97) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL17085846 | 0.80 | TP53 (0.49) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL30186311 | 0.80 | TP53 (0.49) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4080414 | 0.79 | NOX1 (1.00) | NOX1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL8988 | 0.78 | L3MBTL1 (1.00) | NOX1MAPTGAASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671195-B2 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2010-03-02 | — | — | US | disclosed |
| EP-1996568-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2008-12-03 | — | — | EP | disclosed |
| US-7314930-B2 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| WO-2007102352-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2007-09-13 | — | — | WO | disclosed |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-08-03 | — | — | US | disclosed |
| US-7045621-B1 | Process for producing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-05-16 | — | — | US | disclosed |
| EP-1201663-A1 | PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES | Ube Industries, Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | TPMT, BBOX1, NISCH | NOX1 2830/4885MAPT 1561/4885GAA 4292/4885 |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | TST, ADH1C, ADH5 | NOX1 3553/4885MAPT 2277/4885GAA 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.