Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341836 | 0.96 | HDAC3 (0.51) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL29990240 | 0.96 | HDAC3 (0.51) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL3908300 | 0.94 | HDAC3 (0.54) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL29953271 | 0.94 | HDAC3 (0.54) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL3920568 | 0.94 | HDAC3 (0.54) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL6575271 | 0.92 | HSD11B1 (0.50) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| SCHEMBL5209254 | 0.84 | HTR3E (0.55) | HSD11B1MGLLGAAMAPTALDH1A1 | |
| SCHEMBL3918618 | 0.84 | ALDH1A1 (0.47) | HSD11B1MGLLHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL5212698 | 0.82 | HTR3E (0.54) | HSD11B1MGLLGAAMAPTALDH1A1 | |
| SCHEMBL26085824 | 0.82 | KDM4E (0.49) | HSD11B1MGLLHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597915-A | ANTAGONISTS OF CHOLECYSTOKININ AND GASTRIN RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 1997-01-28 | — | — | US | disclosed |
| EP-0549039-B1 | 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists | MERCK SHARP & DOHME (GB) | 1995-08-09 | — | — | EP | disclosed |
| US-5410049-A | Gastrin and cholecystokinin inhibitor | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-25 | — | — | US | disclosed |
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0549039-A1 | 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1993-06-30 | — | — | EP | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |