Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 3/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | AGER | Q15109 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882396 | 0.95 | ASPH (0.50) | ASPHKDM8CYP11B1CYP11B2FFAR1 | |
| SCHEMBL8883428 | 0.92 | CYP11B1 (0.55) | ASPHKDM8IDO1CYP11B1CYP11B2 | |
| SCHEMBL2426791 | 0.83 | LTA4H (0.58) | KDM4EALDH1A1 | |
| SCHEMBL30848623 | 0.83 | LTA4H (0.58) | KDM4EALDH1A1 | |
| SCHEMBL21248064 | 0.82 | ALDH1A1 (0.49) | LMNAKDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL12697756 | 0.81 | KDM4E (0.50) | LMNAKDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL8881039 | 0.81 | PTPN1 (0.55) | LMNAKDM4EMAPTALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10705444 | 0.81 | LTA4H (0.57) | KDM4EALDH1A1 | |
| SCHEMBL1138239 | 0.81 | KDM4E (0.50) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6042801 | 0.80 | PTPN1 (0.51) | LMNAKDM4EMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
| CN-1107144-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1995-08-23 | — | — | CN | disclosed |
| CN-1107145-A | Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1995-08-23 | — | — | CN | disclosed |