Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785130 | 0.89 | MRGPRX4 (0.55) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL27436417 | 0.83 | MRGPRX4 (0.53) | MRGPRX4RXRARXRBNR4A2ROCK2 | |
| SCHEMBL8881827 | 0.82 | KDM4E (0.46) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL30848623 | 0.81 | LTA4H (0.58) | KDM4EALDH1A1RXRARXRBHPGD | |
| SCHEMBL2426791 | 0.81 | LTA4H (0.58) | KDM4EALDH1A1RXRARXRBHPGD | |
| SCHEMBL126180 | 0.81 | MEN1 (0.54) | MRGPRX4KDM4EALDH1A1GAAALOX15 | |
| SCHEMBL8882076 | 0.81 | RXRA (0.56) | MRGPRX4SMN1; SMN2TP53NFKB1NFKB2 | |
| SCHEMBL8884069 | 0.81 | NR4A2 (0.56) | MRGPRX4NR4A2LMNAKMT2A | |
| SCHEMBL8882537 | 0.81 | MAPT (0.52) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| Hydrochloric Acid SCHEMBL10705444 | 0.80 | LTA4H (0.57) | KDM4EALDH1A1RXRARXRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |